Renal failure is where the kidneys fail to adequately filter waste products from the blood.
Classification
Acute kidney injury (AKI), which is abrupt loss of kidney function developing within 7 days. It is often reversible with adequate Tx
Chronic kidney disease (CKD), which is often not reversible
Sx
For acute kidney injury:
Metabolic acidosis
Hyperkalemia
Uremia
Changes in body fluid balance
Effects to other organ systems
For chronic kidney disease:
Increased fluid in body (leading to swelling)
Acidosis
Hypocalcemia
Hyperphosphatemia
Hyperkalemia
Anemia, in later stages
Patient information
So chronic kidney disease causes various electrolyte imbalances. Why does what change?
The kidney excretes urine, so there'll be increased fluid in the body. The kidney creates bicarbonate, so there'll be acidosis. The kidney makes calcitriol, the active form of vitamin D, which helps to increase blood calcium, so there'll be low calcium. Because calcium will be resorbed from bone, there'll be an increase in calcium phosphate, and therefore, also phosphate. The kidneys are also involved with excreting potassium, so if there's problems with it, it can't get rid of it. In fact, even with the phosphate, it's very similar, the kidneys can't excrete it.
Causes
For acute kidney injury:
Decreased renal blood flow (renal ischemia) due to e.g. low blood pressure
Exposure to substances harmful to the kidney
Inflammatory process in the kidney
Obstruction of the urinary tract which impedes the flow of urine
Dx
For acute kidney injury:
Elevated BUN and creatinine
Decreased/absent urine production
For chronic kidney disease:
Determined by a decrease in GFR (i.e. rate at which blood is filtered in the kidney's glomeruli), which is detected by:
Decreased/absent urine production
Increase of waste products (creatinine or urea) in blood
Prognosis
Long term kidney problems associated with cardiovascular disease
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